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  Home >> Trade Lead >> Health & Beauty >> Pharmaceutical Chemicals >> 6-bromoandrostenedione
6-bromoandrostenedione 
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Post Date: December 10, 2007
Expiry Date: June 07, 2008
Company: Wuhan YuanchengTech Development Co.,Ltd 
Contact Person: Mr. Steven yu
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Mr. Steven yu (Manager)
Tel: 86-27-88320830
Fax: 86-27-68886700
Addr: 496 Zhongshan Road, Wuhan Hubei, China (Mainland)
Zip: 430064
HomePage: http://www.yuchengtech.qy6.net (Add to Favorite )
http://www.yuanchengtech.com


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  Detail:

A selective inhibitor of aromatase (estrogen synthetase) would be a useful pharmacological tool with potential therapeutic application. We have found that 6 alpha-bromoandrostenedione (6 alpha-BrA) is a competitive inhibitor of human placental aromatase with respect to androstenedione, with an apparent Ki of 3.4 nM, while 6 beta-BrA is a mechanism-based irreversible inhibitor with an apparent Ki of 0.8 microM and a kinact of 0.025 min-1. Aromatase activity was measured by tritium release into water from the 1 beta position of [1(-3)H,4(-14)C]androstenedione in reaction mixtures containing NADPH and the aromatase.

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